Group sequential tests for delayed responses (with discussion)
نویسندگان
چکیده
منابع مشابه
Group Sequential Tests for Delayed Responses
Group sequential methods are used routinely to monitor clinical trials and to provide early stopping when there is evidence of a treatment effect, lack of an effect, or concerns about patient safety. In many studies, the response of clinical interest is measured some time after the start of treatment and there are subjects at each interim analysis who have been treated but are yet to respond. W...
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Methods have been proposed to re-design a clinical trial at an interim stage in order to increase power. In order to preserve the type I error rate, methods for unplanned design-change have to be defined in terms of non-sufficient statistics and this calls into question their efficiency and the credibility of conclusions reached. We evaluate schemes for adaptive re-design, extending the theoret...
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ژورنال
عنوان ژورنال: Journal of the Royal Statistical Society: Series B (Statistical Methodology)
سال: 2012
ISSN: 1369-7412
DOI: 10.1111/j.1467-9868.2012.01030.x